1.
Biochem Biophys Res Commun
; 709: 149838, 2024 May 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38564939
RESUMO
Dnttip2 is one of the components of the small subunit (SSU) processome. In yeast, depletion of dnttip2 leads to an inefficient processing of pre-rRNA and a decrease in synthesis of the mature 18S rRNA. However, the biological roles of Dnttip2 in higher organisms are poorly defined. In this study, we demonstrate that dnttip2 is a maternal gene in zebrafish. Depletion of Dnttip2 leads to embryonic lethal with severe digestive organs hypoplasia. The loss of function of Dnttip2 also leads to partial defects in cleavage at the A0-site and E-site during 18S rRNA processing. In conclusion, Dnttip2 is essential for 18S rRNA processing and digestive organ development in zebrafish.
Assuntos
Proteínas de Saccharomyces cerevisiae , Peixe-Zebra , Animais , RNA Ribossômico 18S/genética , Peixe-Zebra/genética , Peixe-Zebra/metabolismo , Processamento Pós-Transcricional do RNA , Saccharomyces cerevisiae/metabolismo , Proteínas de Saccharomyces cerevisiae/metabolismo , Precursores de RNA/metabolismo
2.
J Genet Genomics
; 49(3): 249-253, 2022 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34798358